Oestrogen and Progesterone

What is the difference between the progesterone used in HRT and over-the-counter progesterone?

In July 2021 the progesterone-only contraceptive pill was made available over-the-counter in the UK. However, this pill is not the same as the progesterone used in feminising treatments, and should not be used for this purpose. The progesterone-only pill (POP) can be used by transmasculine people as form of contraception or to control monthly cycles, because it will not interfere with masculinising treatments as it does not contain oestrogen. Transfeminine people who want to include progestero...

Can I use over-the-counter progesterone?

The progesterone-only pills made available over the counter in July 2021 are intended for use as a contraceptive or to control monthly cycles, not for feminising hormone replacement therapy (HRT). These can be used by transmasculine people as a contraceptive, but not by transfeminine people as a feminising medication. This is because the progesterone used in HRT is a bioidentical hormone, utrogestan or cyclogest, rather than the progestin that is used for birth control. The progesterone in cont...

What are the benefits and risks of taking progesterone?

Please note: This article refers to the use of bio-identical progesterone for feminisation. This kind of progesterone cannot be used for contraception, and we do not provide the progesterone-only contraceptive pill. To access progesterone for contraceptive purposes, talk to your GP. There have been no well-designed studies of the role of progesterone (progestogens) in feminising hormone regimens. Everyone is different and as such so are the effects of any medication including progesterone. The ...